[5], Common side effects for both forms are:[7], Major side effects requiring medical attention:[7], This medicine is passed through breast milk, so its use during pregnancy or breastfeeding should only be done when clearly needed. Available for Android and iOS devices. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. GENERIC NAME(S): Imipenem-Cilastatin. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics. Bone infection. Developmental toxicity studies with imipenem and cilastatin sodium (alone or in combination) administered to mice, rats, rabbits, and monkeys at doses 0.4 to 2.9 times the recommended human dose (RHD), (based on body surface area), showed no drug-induced fetal malformations [6] Primaxin is cleared from the body by the kidneys, so it is important to tell one's doctor about any other drugs being taken that are also cleared through the kidneys (such as other antibiotics), especially for older patients, as kidney function declines with age. [1] It is given by injection into a vein or muscle. Powder for solution for infusion 1 × 20ml Vial per pack. * Tienam I.V. Important: The information below refers to products available in the United States that contain imipenem. [1], Imipenem/cilastatin was first sold in 1987. Compare Products: Select up to 4 products. Imipenem+Cilastatin+500500 Mg 1 Unit Parenteral Use. [1] Other side effects may include Clostridium difficile diarrhea and allergic reactions including anaphylaxis. [1] It is unclear if use during pregnancy is safe for the baby. Imipenem is a beta-lactam antibiotic that is used in combination with cilastatin to treat infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc. Search results for Imipenem at Sigma-Aldrich. This antibiotic is used to treat serious infections that are mild to moderate in severity, such as lower respiratory infection, heart valve infection, infection caused by a burst appendix, and some abscesses. H2O that is derived from a bacterium (Streptomyces cattleya) and is effective against gram-negative and gram-positive bacteria. Imipenem/cilastatin/relebactam, sold under the brand name Recarbrio, is a fixed-dose combination medication used as an antibiotic. Intravenous: 250mg imipenem, 250mg cilastatin, and 10mg sodium bicarbonate power mixture for intravenous injection. Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections. Overview. [2] Imipenem is in the carbapenem family of medications and works by interfering with the bacteria's cell wall. Its use is generally restricted to severe infections largely in hospitalized patients. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. 500mg imipenem, 500mg cilastatin, and 20mg sodium bicarbonate power mixture for … Application Number. [1] Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. The brand name of the imipenem-cilastatin combination is Primaxin, and the prescribed dose of Primaxin is understood to refer to the amount of the imipenem component being administered. Imipenem is a broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. cilastatin/imipenem systemic. Brand names: Primaxin IV, Primaxin IM. Cilastatin/imipenem systemic is used in the treatment of: Aspiration Pneumonia. Imipenem (hydrate) SAFETY DATA SHEET Supersedes Revision: 10/28/2014 according to Regulation (EC) No. Search results for imipenem at Sigma-Aldrich. Imipenem. Little information is available on possible cross-sensitivity to liver injury among the different betalactam antibiotics, but patients with clinically apparent liver injury due to imipenem should probably avoid the other carbapenems. Bacterial Infection. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. The course is usually self-limiting, but at least one case of vanishing bile duct syndrome related to the carbapenems has been reported. The .gov means it’s official. Half-life (both drugs): 60 min; prolonged with renal impairment. Imipenem and Cilastatin. Some patients may benefit from symptomatic therapy of the pruritus associated with cholestasis using antihistamines, ursodiol, or cholestyramine. “Primaxin” the brand of Originator Merck & Co. contains Imipenem & Cilastatin, a new beta-lactam agent of the carbapenem class (1-Beta-methyl carbapenem). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Imipenem (hydrate) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. Imipenem/cilastatin has the ability to kill a wide variety of bacteria. The drug is distributed rapidly and widely to most tissues and fluids, including sputum, pleural fluid, peritoneal fluid, interstitial fluid, bile, aqueous humor, reproductive organs, and bone; highest concentrations occur in pleural fluid, interstitial fluid, peritoneal fluid, and reproductive organs; low concentrations occur in CSF; it crosses the placenta, and enters breast milk. Imipenem; Imipenem/cilastatin (Brand name: Primaxin) Doripenem (Brand name: Doribax) Meropenem (Brand name: Merrem) Ertapenem (Brand name: Invanz) Contents. It works by stopping the growth of bacteria. Primaxin is an antibiotic useful for the treatment of a number of bacterial infections. The cholestatic hepatitis attributed to imipenem-cilastatin and the carbapenems is probably immunoallergic and resembles the rare, clinically apparent liver injury that has been linked to penicillins and cephalosporins. Generic Name: Imipenem and Cilastatin (i mi PEN em & sye la STAT in) Brand Name: Primaxin I.V. Imipenem/Cilastatin is a topic covered in the Johns Hopkins ABX Guide.. To view the entire topic, please sign in or purchase a subscription.. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Brand names: Primaxin IV, Primaxin IMDrug class(es): carbapenemsCilastatin/imipenem systemic is used in the treatment of: Brand names: RecarbrioDrug class(es): carbapenems/beta-lactamase inhibitorsCilastatin/imipenem/relebactam systemic is used in the treatment of: → Search the entire Drugs.com site for imipenem. Get information of companies selling wide range of imipenem along with latest price, moq & product details. How to use imipenem in a sentence. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. [9] Medically reviewed by Drugs.com. Brand Name. In 2019, it was approved for use in the United States for the treatment of complicated urinary tract and complicated intra-abdominal infections. [5] Compare Products: Select up to 4 products. 1 × 20ml Vial. *Please select more than one item to compare *Please select more than one item to compare The latency to onset has been within one to three weeks, and the pattern of enzyme elevations is usually cholestatic. … Imipenem-Cilastatin Suspension For Reconstitution. In large clinical trials, imipenem was associated with transient and asymptomatic elevations in serum aminotransferase levels in about 6% of patients given the drug for five to 14 days. - 500 INJECTION. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Find imipenem at best price offered by imipenem manufacturers, imipenem suppliers, dealers, traders and exporters. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is commercially available as Primaxin as 250-mg or 500-mg infusion bottles for IV use or 500-mg or 750-mg vials of lyophilized powder for IM injection. OTHER NAME(S): Imipenem-Cilastatin Suspension For Reconstitution It … View all Brand Names Innovator's Monograph Indications The activity of Cilastatin & Imipenem against an unusually broad spectrum of pathogens makes it particularly useful in the treatment of polymicrobic mixed aerobic/anaerobic infections as well as initial therapy prior to … More serious hepatic injury from imipenem/cilastatin is rare, but jaundice and liver test abnormalities have been reported in 0.1% of patients in prospective trials of the agent. Drug class (es): carbapenems. caused by various types of bacteria. Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. [6], World Health Organization's List of Essential Medicines, "Cilastatin / imipenem Use During Pregnancy | Drugs.com", "Imipenem and Cilastatin Sodium Injection", https://en.wikipedia.org/w/index.php?title=Imipenem/cilastatin&oldid=983527147, World Health Organization essential medicines, Chemical pages without DrugBank identifier, Multiple chemicals in an infobox that need indexing, Drugs that are a combination of chemicals, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 14 October 2020, at 19:00. [1] Cilastatin blocks the activity of dehydropeptidase I which prevents the breakdown of imipenem. 1 vial EV 500 mg + 500 mg. Approval Date. Federal government websites often end in .gov or .mil. Dosage Strength. Continue Learning about Antibiotic 6 Ailments That Call for an Antibiotic The most common side effects of imipenem are diarrhea, nausea, vomiting, skin rash, pruritus, and injection-site reactions. Cilastatin is in a class of medications called dehydropeptidase inhibitors. Immunoallergic features can occur, but autoantibodies are rare. Imipenem/cilastatin is indicated for the treatment of severe or complicated skin, tissue, joint, respiratory tract, intra-abdominal, urinary tract and urogenital infections, but not meningitis (as it does not pass through the blood brain barrier), endocarditis, and sepsis due to susceptible organisms. Structure, Function, and Resistance It is important tell one's doctor or pharmacist one's medical history, especially of brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, and stomach/intestinal diseases (e.g., colitis).[5]. 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